Tuesday 24 June 2014

Secret behind why Alzheimer’s patients cannot make new memories discovered

Scientists discover molecule that stops new memories forming in people with Alzheimer's disease, raising hopes of new drugs to treat dementia.

A microscopic view showing high concentrations of the GABA neurotransmitter (red) in the reactive astrocytes (green) in a human brain with Alzheimer's disease

A drug to prevent the devastating memory loss associated with Alzheimer's disease is a step closer after scientists discovered the secret behind why people with dementia cannot form new memories.

It was previously thought that Alzheimer's was primarily caused by the build up of sticky amyloid plaques in the brain which stop neurons from firing.

But drugs to clear the plaques have so far failed to bring any improvement to sufferers.

Many scientists believe that the amyloid plaques trigger a 'cascade effect' of other symptoms meaning that by the time they are spotted it is already too late.

Researchers at Penn State University have now discovered that those plaques may be triggering overproduction of a chemical that drives memory loss by preventing a key part of the brain from functioning.